Meet the Lab

Lab Members


X. Shirley Liu, Ph.D.
Principal Investigator
xsliu@jimmy.harvard.edu



X. Shirley Liu received a PhD in Biomedical Informatics and a PhD minor in Computer Science from Stanford University in 2002. She is a Professor with the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute and Harvard School of Public Health. Shirley is a computational biologist with expertise in cancer epigenetics. Her research focuses on algorithm development and integrative mining from big data generated on microarrays, massively parallel sequencing, and other high throughput techniques to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance.

Cliff Meyer, Ph.D.
Research Scientist
cliff@jimmy.harvard.edu



Cliff received his PhD in Chemical Engineering at Princeton University. He is developing methods to analyze and interpret genome-wide DNA microarray assays of transcription and protein-DNA interactions. His approach is to integrate physical and chemical insights with statistical models of DNA hybridization in order to distinguish biologically relevant signal from technical artifact. He is also working on mathematical models of transcriptional behavior that integrate microarray data with DNA sequence data.

Wei Li, Ph.D.
Postdoctoral Fellow
wli@jimmy.harvard.edu
scholar.harvard.edu/weili



Wei received his Ph.D. in computer science at University of California, Riverside, followed by his bachelor and master degrees in computer science at Tsinghua University. He is interested in developing computational methodology for the modeling and analysis of genetic screens, especially the new CRISPR/Cas9 screens. He is also working on using CRISPR screens to study the functions of coding and non-coding elements in the context of human cancer and disease.

Peng Jiang, Ph.D.
Postdoctoral Fellow
pjiang@jimmy.harvard.edu



Peng received his PhD from the department of computer science at Princeton University. His major work is in developing methods to find patterns and functional output of combinatorial interplay between biological regulators, such as between Transcription factors or between RNA binding proteins and microRNAs. He is interested in further exploring the impact of combinational regulation in cancer and biomedical research.

Xiaoqing Wang, M.D., Ph.D.
Postdoctoral Fellow
Xiaoqing_Wang@dfci.harvard.edu



Xiaoqing is a postdoc who received his M.D. in cardiology from Dalian Medical University in China. His current research is focused on identifying new target protein which can affect proliferation and metastasis of breast cancer in vivo by genome-wide screening.

Jingyu Peng, Ph.D.
Postdoctoral Fellow
jingyu_peng@dfci.harvard.edu



Jingyu received her Ph.D. in Molecular Biology and Biochemistry from Peking University. She is interested in developing CRISPR-related genetic methodologies to investigate critical genes or genetic mutations that are responsible for tumorigenesis of prostate cancer and breast cancer.

Shengqing Gu, Ph.D.
Postdoctoral Fellow
shenqging_gu@dfci.harvard.edu



Shenqging received his Ph.D. in Medical Biophysics at University of Toronto. He is interested in studying cancer immunology, especially the mechanisms of response/resistance to immune checkpoint inhibitors, and optimization of combination of immunotherapy and conventional therapies.

Xihao Hu, Ph.D.
Postdoctoral Fellow
xhu@jimmy.harvard.edu



Xihao received his Ph.D. in Computer Science at Chinese University of Hong Kong. He is interested in studying the three-dimensional genome structure in order to infer the relationships among regulatory elements and their gene targets.

Qin Tang, Ph.D.
Postdoctoral Fellow
Qin_Tang@DFCI.Harvard.edu



Qin received her B.S. from Nanjing University in 2012 and PhD from the Harvard BBS program in 2017. She is excited to explore new bench technologies and incorporate computational methods to study the dynamics of heterogeneous tumor cell populations in vivo.

Mark Lee, M.D., Ph.D.
Clinical Fellow
MLEE19@PARTNERS.ORG



Mark received his M.D. at Harvard Medical School and his Ph.D. in Immunology at Harvard. He currently trains in Clinical Pathology at the Brigham and Women's Hospital. He studies inter-individual variation in the human immune system, and applications for diagnosis.

Avinash Sahu, Ph.D.
Postdoctoral Fellow
avinash_sahu@DFCI.harvard.edu



Avinash finished his Ph.D. in Computer Science from the University of Maryland following his M.S. from EPFL, Switzerland. His research interests lie in developing Big data and Bayesian approaches to integrate and analyze biological data. His current research is focussed on developing methods for the genomic analysis of cancer and cardiovascular diseases.

Chen-Hao Chen, Ph.D.
Research Assistant
chenhaochen@fas.harvard.edu



Chen-Hao received his Ph.D. at Harvard Medical School in June 2017 and his M.D. from National Taiwan University. He is currently working on synthetic lethality in cancers.

Jian Zhang
Visiting Graduate Student
jzhang@jimmy.harvard.edu



Jian is a PhD candidate from Beijing Institute of Basic Medical Sciences, China. His current research focuses on understanding tumor heterogeneity through integrative analysis of cancer omic data.

Ziyi Li
Visiting Graduate Student
ziyi_li@dfci.harvard.edu



Ziyi is a PhD candidate from Tongji University, Shanghai, China. She is interested in using CRISPR Screen, Genomic and Transcriptomic Feature to investigate target drug resistance in cancer cells.

Binbin Wang
Visiting Graduate Student
binbin_wang@dfci.harvard.edu



Binbin is a PhD candidate from Tongji University, Shanghai, China. He is interested in developing computational methodology for the analysis of CRISPR/Cas9 screens to investigate the mechanism of drug response and resistance. He is also interested in cancer immunology and is currently working on neo-antigen prediction.

Len Taing
Bioinformatics Engineer
lentaing@jimmy.harvard.edu



Len received his masters in Psychological & Brain Sciences at the John Hopkins University in Baltimore, MD. He is currently working on developing the Cistrome Data Analysis Pipeline with other members of the lab. He also supports the lab by developing code and helping debug and maintain the code written by others.

Nicole Traugh
Research Technician
NicoleC_Traugh@DFCI.HARVARD.EDU



Nicole received her B.S. in Biology from Saint Michael's College in Vermont. She is interested in cancer immunology, genetics and infectious disease. Her current work involves set up for the in vivo CRISPR screen platform, as well as performing CRISPR screens in vivo and in vitro.

Shawn Mims
Grants Management Specialist
ChristoperS_Mims@dfci.harvard.edu



Shawn is Shirley's Grant Manager.

Jean Ryan
Program Administrator
jeanryan@jimmy.harvard.edu



Jean is Program Administrator to Shirley.

Alumni (with at least a 6 month stay)

Postdoctoral Fellows and Current Status:



Students and Current Status:


Visiting Scholars and PhD Students: