Meet the Lab

Lab Members

X. Shirley Liu, Ph.D.
Principal Investigator

X. Shirley Liu received a PhD in Biomedical Informatics and a PhD minor in Computer Science from Stanford University in 2002. She is a Professor with the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute and Harvard School of Public Health. Shirley is a computational biologist with expertise in cancer epigenetics. Her research focuses on algorithm development and integrative mining from big data generated on microarrays, massively parallel sequencing, and other high throughput techniques to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance.

Cliff Meyer, Ph.D.
Research Scientist

Cliff received his PhD in Chemical Engineering at Princeton University. He is developing methods to analyze and interpret genome-wide DNA microarray assays of transcription and protein-DNA interactions. His approach is to integrate physical and chemical insights with statistical models of DNA hybridization in order to distinguish biologically relevant signal from technical artifact. He is also working on mathematical models of transcriptional behavior that integrate microarray data with DNA sequence data.

Wei Li, Ph.D.
Postdoctoral Fellow

Wei received his Ph.D. in computer science at University of California, Riverside, followed by his bachelor and master degrees in computer science at Tsinghua University. He is interested in developing computational methodology for the modeling and analysis of genetic screens, especially the new CRISPR/Cas9 screens. He is also working on using CRISPR screens to study the functions of coding and non-coding elements in the context of human cancer and disease.

Peng Jiang, Ph.D.
Postdoctoral Fellow

Peng received his PhD from the department of computer science at Princeton University. His major work is in developing methods to find patterns and functional output of combinatorial interplay between biological regulators, such as between Transcription factors or between RNA binding proteins and microRNAs. He is interested in further exploring the impact of combinational regulation in cancer and biomedical research.

Bo Li, Ph.D.
Postdoctoral Fellow

Bo received his PhD in Bioinformatics at the University of Michigan, Ann Arbor. Tumor survives multiple challenges, including host immune response, internal selective pressure and therapeutic intervention due to its large pool of divergent cells that allow rapid adaptation and continuous evolution. Bo is currently interested in understanding the nature of intra-tumor heterogeneity and its clinical impact by integration of multiple types of high-throughput data.

Tengfei Xiao, Ph.D.
Postdoctoral Fellow

Tengfei received his Ph.D. in Bioinformatics from the Chinese Academy of Sciences, Biophysics Institute. In joining our lab, Tengfei concentrates most of his time to investigating chromatin dynamic change and transcriptional regulation network in cancers. He has also shown interest in developing new methodology for studying nucleosome positions and chromatic structures.

Xiaoqing Wang, M.D., Ph.D.
Postdoctoral Fellow

Xiaoqing is a postdoc who received his M.D. in cardiology from Dalian Medical University in China. His current research is focused on identifying new target protein which can affect proliferation and metastasis of breast cancer in vivo by genome-wide screening.

Jingyu Peng, Ph.D.
Postdoctoral Fellow

Jingyu received her Ph.D. in Molecular Biology and Biochemistry from Peking University. She is interested in developing CRISPR-related genetic methodologies to investigate critical genes or genetic mutations that are responsible for tumorigenesis of prostate cancer and breast cancer.

Shengqing Gu, Ph.D.
Postdoctoral Fellow

Shenqging received his Ph.D. in Medical Biophysics at University of Toronto. He is interested in studying cancer immunology, especially the mechanisms of response/resistance to immune checkpoint inhibitors, and optimization of combination of immunotherapy and conventional therapies.

Xihao Hu, Ph.D.
Postdoctoral Fellow

Xihao received his Ph.D. in Computer Science at Chinese University of Hong Kong. He is interested in studying the three-dimensional genome structure in order to infer the relationships among regulatory elements and their gene targets.

Qin Tang, Ph.D.
Postdoctoral Fellow

Qin received her B.S. from Nanjing University in 2012 and PhD from the Harvard BBS program in 2017. She is excited to explore new bench technologies and incorporate computational methods to study the dynamics of heterogeneous tumor cell populations in vivo.

Xiaofang Xing, M.D./Ph.D.
Visiting Scientist

Xiaofang is a visiting schientist from Peking University Cancer Hospital, who received her Ph.D. in molecular biochemistry and M.D. in clinical medicine from Peking University, China. She is interested in the translational research in gastrointestinal cancer focusing on the tumor marker screening and immunotherapy.

Taiwen Li
Visiting Scientist

Taiwen is a Visiting Scientist from West China College of Stomatology at the Sichuan University, Chengdu, China. His research is discovering mutational patterns during the evolution of cancer. His current work is studying the mutation rate variability in cancer.

Chen-Hao Chen, Ph.D.
Research Assistant

Chen-Hao received his Ph.D. at Harvard Medical School in June 2017 and his M.D. from National Taiwan University. He is currently working on synthetic lethality in cancers.

Yingbo Cui
Visiting Graduate Student

Yingbo is a PhD candidate from the National University of Defense Technology, Changsha, China. He is interested in developing fast and efficient algorithms for computational biology. He is currently working on analysis and visualization of genome-wide CRISPR screen data.

Jian Zhang
Visiting Graduate Student

Jian is a PhD candidate from Beijing Institute of Basic Medical Sciences, China. His current research focuses on understanding tumor heterogeneity through integrative analysis of cancer omic data.

Ziyi Li
Visiting Graduate Student

Ziyi is a PhD candidate from Tongji University, Shanghai, China. She is interested in using CRISPR Screen, Genomic and Transcriptomic Feature to investigate target drug resistance in cancer cells.

Binbin Wang
Visiting Graduate Student

Binbin is a PhD candidate from Tongji University, Shanghai, China. He is interested in developing computational methodology for the analysis of CRISPR/Cas9 screens to investigate the mechanism of drug response and resistance. He is also interested in cancer immunology and is currently working on neo-antigen prediction.

Len Taing
Bioinformatics Engineer

Len received his masters in Psychological & Brain Sciences at the John Hopkins University in Baltimore, MD. He is currently working on developing the Cistrome Data Analysis Pipeline with other members of the lab. He also supports the lab by developing code and helping debug and maintain the code written by others.

Nicole Traugh
Research Technician

Nicole received her B.S. in Biology from Saint Michael's College in Vermont. She is interested in cancer immunology, genetics and infectious disease. Her current work involves set up for the in vivo CRISPR screen platform, as well as performing CRISPR screens in vivo and in vitro.

Jean Ryan
Program Administrator II

Jean is Program Administrator to Shirley. Her door is always opened to the Liu Lab for whatever assistance they may need. She is happy being wife, mom, grandma and friend.

Alumni (with at least a 6 month stay)

Postdoctoral Fellows and Current Status:

Students and Current Status:

Visiting Scholars and PhD Students: