Meet the Lab

Lab Members

X. Shirley Liu, Ph.D.
Principal Investigator

X. Shirley Liu received a PhD in Biomedical Informatics and a PhD minor in Computer Science from Stanford University in 2002. She is a Professor with the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute and Harvard School of Public Health. Shirley is a computational biologist with expertise in cancer epigenetics. Her research focuses on algorithm development and integrative mining from big data generated on microarrays, massively parallel sequencing, and other high throughput techniques to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance.

Cliff Meyer, Ph.D.
Research Scientist

Cliff received his PhD in Chemical Engineering at Princeton University. He is developing methods to analyze and interpret genome-wide DNA microarray assays of transcription and protein-DNA interactions. His approach is to integrate physical and chemical insights with statistical models of DNA hybridization in order to distinguish biologically relevant signal from technical artifact. He is also working on mathematical models of transcriptional behavior that integrate microarray data with DNA sequence data.

Peng Jiang, Ph.D.
Postdoctoral Fellow

Peng received his PhD from the department of computer science at Princeton University. His major work is in developing methods to find patterns and functional output of combinatorial interplay between biological regulators, such as between Transcription factors or between RNA binding proteins and microRNAs. He is interested in further exploring the impact of combinational regulation in cancer and biomedical research.

Xiaoqing Wang, M.D., Ph.D.
Postdoctoral Fellow

Xiaoqing is a postdoc who received his M.D. in cardiology from Dalian Medical University in China. His current research is focused on identifying new target protein which can affect proliferation and metastasis of breast cancer in vivo by genome-wide screening.

Jingyu Peng, Ph.D.
Postdoctoral Fellow

Jingyu received her Ph.D. in Molecular Biology and Biochemistry from Peking University. She is interested in developing CRISPR-related genetic methodologies to investigate critical genes or genetic mutations that are responsible for tumorigenesis of prostate cancer and breast cancer.

Shengqing Gu, Ph.D.
Postdoctoral Fellow

Shenqging received his Ph.D. in Medical Biophysics at University of Toronto. He is interested in studying cancer immunology, especially the mechanisms of response/resistance to immune checkpoint inhibitors, and optimization of combination of immunotherapy and conventional therapies.

Xihao Hu, Ph.D.
Postdoctoral Fellow

Xihao received his Ph.D. in Computer Science at Chinese University of Hong Kong. He is interested in studying the three-dimensional genome structure in order to infer the relationships among regulatory elements and their gene targets.

Qin Tang, Ph.D.
Postdoctoral Fellow

Qin received her B.S. from Nanjing University in 2012 and PhD from the Harvard BBS program in 2017. She is excited to explore new bench technologies and incorporate computational methods to study the dynamics of heterogeneous tumor cell populations in vivo.

Mark Lee, M.D., Ph.D.
Clinical Fellow

Mark received his M.D. at Harvard Medical School and his Ph.D. in Immunology at Harvard. He currently trains in Clinical Pathology at the Brigham and Women's Hospital. He studies inter-individual variation in the human immune system, and applications for diagnosis.

Avinash Sahu, Ph.D.
Postdoctoral Fellow

Avinash finished his Ph.D. in Computer Science from the University of Maryland following his M.S. from EPFL, Switzerland. His research interests lie in developing Big data and Bayesian approaches to integrate and analyze biological data. His current research is focussed on developing methods for the genomic analysis of cancer and cardiovascular diseases.

Chen-Hao Chen, Ph.D.
Research Assistant

Chen-Hao received his Ph.D. at Harvard Medical School in June 2017 and his M.D. from National Taiwan University. He is currently working on synthetic lethality in cancers.

Reiko Nishihari, Ph.D.
Assistant Professor

Reiko obtained a PhD in Health Sciences from Osaka University and is currently pursuing the SM program in Computational Biology and Quantitative Genetics at the Harvard T.H. Chan School of Public Health. Her research focuses on genomics, immunology, epidemiology and bioninformatics in cancer with a core goal of developing new strategies for cancer prevention, early detection and treatment. Her expertise includes designing, alalyzing and interpreting studies from high-dimensional large population/clinical databases.

Jian Zhang
Visiting Graduate Student

Jian is a PhD candidate from Beijing Institute of Basic Medical Sciences, China. His current research focuses on understanding tumor heterogeneity through integrative analysis of cancer omic data.

Rongbin Zheng
Visiting Graduate Student

Rongbin is a PhD candidate from Tongji University, Shanghai, China. His research focuses on gene regulation in cancer and immune cells.

Jingxin Fu
Visiting Graduate Student

Jingxin is a PhD candidate from Tongji University, Shanghai, China. She is interested in using computational biology approaches to predict immunotherapy response.

Jin Wang
Visiting Graduate Student

Jin is a PhD candidate from Tongji University, Shanghai, China. She is interested in cancer immunology, especially identifying cancer-specific immune characteristics from BCR repertoire.

Peter Shen
M.S. Candidate

Peter is a masters candidate in Biomedical Informatics at Harvard Medical School. His interests are in personalized and preventative medicine, especially in cancer. He is striving to deliver deeper insights from 'omics data into clinical applications at the bedside.

Yushi Tang
M.S. Candidate

Yushi received his B.S. and B.A. from Peking University. He is now a M.S. candidate at the Department of Biostatistics, Harvard T.H. Chan School of Public Health. He is interested in developing statistical and computational methods to integrate both cancer genomic and epigenetic data to understand GWA SNPs from different perspectives.

Len Taing
Bioinformatics Engineer

Len received his masters in Psychological & Brain Sciences at the John Hopkins University in Baltimore, MD. He is currently working on developing the Cistrome Data Analysis Pipeline with other members of the lab. He also supports the lab by developing code and helping debug and maintain the code written by others.

Nicole Traugh
Research Technician

Nicole received her B.S. in Biology from Saint Michael's College in Vermont. She is interested in cancer immunology, genetics and infectious disease. Her current work involves set up for the in vivo CRISPR screen platform, as well as performing CRISPR screens in vivo and in vitro.

Shawn Mims
Grants Management Specialist

Shawn is Shirley's Grant Manager.

Jean Ryan
Program Administrator

Jean is Program Administrator to Shirley.

Alumni (with at least a 6 month stay)

Postdoctoral Fellows and Current Status:

Students and Current Status:

Visiting Scholars and PhD Students: