Positions

1. Experimental Postdoctorate

Description:

The laboratory of Professor X. Shirley Liu (http://liulab.dfci.harvard.edu/, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard School of Public Health) invites applications to an experimental postdoctoral position. The research in the Liu laboratory focuses on using pioneering genomic technology and integrative computational modeling to study cancer gene regulation. We developed many widely used and cited computational algorithms for transcription factor motif finding, ChIP-chip/seq analysis and integration (Liu et al, Nat Biotech 2002; Zhang et al, Genome Biol 2008; Gerstein et al, Science 2010), identified many novel characteristics of epigenetic profiles and chromatin regulators (Oszolak et al, Nat Biotech 2007; He et al, Nat Genet 2010; Vastenhouw et al, Nat 2010; Xu et al, Science 2012; He et al, Nat Method 2014), and revealed the mechanism of transcription factors and lncRNAs mis-regulated in cancer (Carroll et al, Nat Genet 2006; Lupien et al, Cell 2008; Wang et al, Cell 2009; Du et al, NSMB 2013; Wang et al, PNAS 2014). X. Shirley Liu has an H-index of 58 and total citation of over 15K. Since becoming a faculty in 2003, she has mentored 9 trainees to tenure track faculty positions. We are looking for an experimental postdoctoral fellow under the joint supervision of X. Shirley Liu and Myles Brown at the Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute. We have recently developed computational methods to predict efficient gRNA for CRISPR-Cas9 knockout and for calling hits from genome-wide CRISPR-Cas9 knockout screens (Li et al, Genome Biol 2014), and have optimized the screening experimental conditions. In the coming year, we will embark on a number of exciting experimental projects using this technology, including but not exclusive of: precision medicine using CRISPR-Cas9 knockout screens on patient tumor-derived cancer cell lines; identifying response biomarkers and resistant mechanisms to targeted cancer drugs, especially epigenetic drugs; large scale prediction and validation of synthetic lethal genes in cancer cells; screening for functional cis-elements and lncRNA genes in cancer genomes; using CRISPR-Cas9 tagging to study genome-wide binding of transcription and chromatin factors in wild type and mutation conditions.

Requirements:

Ideal applicant should have:


Application Process:

Interested applicants should submit a letter of interest with a one-page proposal for a project to be conducted in the Liu Lab, CV, and three references (including name and contact information) to xsliu (At) jimmy (Dot) harvard (Dot) edu with subject line “Experimental postdoctoral application”.


2. Postdoctorate

Description:

The laboratory of Professor X. Shirley Liu (http://liulab.dfci.harvard.edu/, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard School of Public Health) invites applications for a postdoctoral position. The research in the laboratory focuses on designing bioinformatics algorithms (Liu et al, Nat Biotech 2002; Zhang et al, Genome Biol 2008) and designing integrative genomics approaches (He et al, Nat Genet 2010) to understand transcriptional and epigenetic regulation in development and diseases (Carroll et al, 2006; Oszolak et al, Nat Biotech 2007; Lupien et al, Cell 2008; Wang et al, Cell 2009; Vastenhouw et al, Nat 2010; Feng et al, Science 2011; Xu et al, Science 2012). A representative list of current projects includes: design a fast algorithm to search all public ChIP/DNase-seq for relevant data and regulatory logic; integrate ChIP/DNase-seq data to mine The Cancer Genome Atlas data; use chromatin dynamics to understand cell differentiation and cancer drug targets; predict cancer drug sensitivity and synthetic lethal pathways in cancer cells; model the genetic and epigenetic mechanisms underlying cancer drug resistance; identify and characterize cancer-related lncRNAs. Since becoming a faculty in 2003, the PI has mentored 9 trainees to tenure track faculty positions.

Requirements:

Ideal applicant should have:

Application Process:

Interested applicants should submit a letter of interest with a one-page proposal for a project to be conducted in the Liu Lab, CV, and three references (including name and contact information) to xsliu (At) jimmy (Dot) harvard (Dot) edu with subject line “Postdoctoral application”.



Last modified by JR in December, 2015.