The laboratory of Professor X. Shirley Liu at Dana-Farber Cancer Institute and Harvard T.H.Chan School of Public Health invites applicants for the following positions. The research in the laboratory focuses on designing bioinformatics algorithms and integrative genomics approaches to model gene regulation, find novel drug targets and combinations, and predict response to targeted and immunotherapies in cancer.

A representative list of recent projects and publications (with Liu Lab as major contributors) include:


Experimental Research Technician in Cancer Research

The research technician will be an important member of our team, and will be engaged in various experimental projects applying a variety of techniques, such as molecular cloning, CRISPR screen, cancer-immune co-culture, mouse in vivo operations, and single-cell profiling technologies. Besides bench-based research, responsibilities will also include some aspects of laboratory management and maintenance.

We believe that the successful operation of the whole lab relies on the realization of personal goals of every member. Therefore, we encourage and assist comprehensive self-improvement, and provide training in both experimental and computational approaches to our members. We also encourage and support our technicians to further pursue their scientific career after their stay with us.

The Liu lab is a vibrant and happy family, where members are very supportive of each other. In addition to the intensive academic work, we organize after-work games/parties/trips to enrich ourselves.


  • Bachelor’s Degree (by Sep 2019) required with a major in biology or chemistry preferred.
  • Excellent communication and collaboration skills.
  • Excellent logical skills and learning ability.
  • Pay attention to details and be thorough in completing work tasks. 

Contact Shirley Liu at: with subject line "Experimental Research Technician application".

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

APPLY | Subject Line “Experimental Research Technician application”

Lead Computational Biologist, Cancer Immunologic Data Commons (CIDC)

Dana-Farber Cancer Institute (DFCI) was recently awarded a five-year grant from the National Cancer Institute (NCI) as part of the Cancer Moonshot Project to build a Cancer Immunologic Data Commons (CIDC). NCI plans to conduct comprehensive profiling of tumor, blood, and fecal samples from NCI-sponsored immuno-oncology trials at four Cancer Immune Monitoring and Analysis Centers (CIMACs: Stanford, MD Anderson, Mt Sinai, and DFCI). The CIDC is responsible for building the database infrastructure, bioinformatics pipelines, computational algorithms for the resulting profiling data and related clinical data, enabling integrated analysis across trials and sharing of all data by the larger immuno-oncology research community. The goal of the project is to enable systematic incorporation of biomarker studies in NCI-supported early immunotherapy clinical trials to better understand and predict which patients respond to certain immunotherapy treatments.

The CIDC project currently seeks a Lead Computational Biologist for the CIDC. The Lead Computational Biologist will work closely with laboratories of DFCI, CIMAC and CIDC investigators, especially laboratories of Drs. X. Shirley Liu, Ethan Cerami, Catherine Wu, and Steve Hodi on various bioinformatics aspects of immune-profiling tools and analyses. We are looking for exceptional candidates with strong computational biology, immunogenomics, and communication skills.


Computational Biology Postdoc Position at the X. Shirley Liu Lab

Ideal applicant should have:

    1. A PhD degree in related field (bioinformatics, physics, statistics, engineering, etc) received in the last 3 years
    2. Strong quantitative background (machine learning, Bayesian inference, etc.) or computational genomics experiences (high throughput sequence analysis, etc.)
    3. Strong programming skills: ((Python | C | C++ | Java) & R)
    4. At least two first authored English papers (or three if co-first authors) with submitted, accepted or published status in journals
    5. Good spoken and written communication skills in English

Interested applicants should submit CV, a letter of interest with a one-page proposal for a project to be conducted in the Liu Lab, and contact of three references to xsliu (At) jimmy (Dot) harvard (Dot) edu with subject line “Postdoctoral application”.

APPLY | Subject Line “Postdoctoral application”

Data Scientist in Translational Cancer Research

The Shirley Liu Lab is recruiting a data scientist to develop machine learning algorithms and pipelines, build databases and interactive web servers, and conduct high throughput data analyses and integration to model tumor immunology and understand cancer patient response to immunotherapy. We recently received funding for a Cancer Moonshot Project by the National Cancer Institute to build a Cancer Immunologic Data Commons (CIDC). NCI plans to conduct comprehensive profiling of clinical samples from immuno-oncology trials. The data scientist will work on various computational aspects of immune-profiling algorithms and analyses, with the goal of identifying biomarkers for optimizing immunotherapy strategies in cancer.

APPLY | subject line “Data scientist application”